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The effect of orally administered epigallocatechin-3-gallate on ligature-induced periodontitis in rats

Journal name：Journal of Periodontal Research
Literature No.：
Literature Url： http://onlinelibrary.wiley.com/doi/10.1111/jre.12071/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=
Date publication：December 2013

Abstract

Background and Objective

Epigallocatechin-3-gallate (EGCG) is known for its beneficial properties, including anti-inflammatory and anti-oxidative activities. Recently, reports have suggested that EGCG plays a pivotal role in regulating cytokine expression and osteoclastic activity. In the present study, we investigated whether orally administered EGCG has a therapeutic effect on ligature-induced periodontitis.

Materials and Methods

Forty-eight Sprague–Dawley rats were treated with EGCG or phosphate-buffered saline. Periodontitis was induced by tying a ligature for 7 d. After removing ligation, EGCG (200 mg/kg) or phosphate-buffered saline was administered via oral gavage on a daily basis. Rats were killed after 1, 2 and 4 wk of administration. Histologic and histomorphometric analyses, tartrate resistant acid phosphatase staining and immunohistochemistry were carried out.

EGCG (99% purity, Chengdu Biopurify Phytochemicals Ltd., Sichuan, China