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Home > Product Category > Botanical Source > Aconitum carmichaelii Debx.


CAS No.:2752-64-9

Catalogue No.: BP0935
Formula: C33H45NO11
Mol Weight: 631.719
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Product name: Mesaconitine
Synonym name: N-Desethyl-N-methylaconitine; Japaconitine A; Japaconitine B
Catalogue No.: BP0935
Cas No.: 2752-64-9
Formula: C33H45NO11
Mol Weight: 631.719
Botanical Source: Alkaloid from Aconitum manschuricum and many other Aconitum spp. (Ranunculaceae)
Physical Description: White powder
Type of Compound: Alkaloids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Mesaconitine increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces, suggests that mesaconitine-induced Ca2+ influx and activation of nitric-oxide synthase in endothelial cells and, thus, induced vasorelaxation in rat aorta.[1]
Mesaconitine is highly toxic, can inhibit Efflux transporters, including P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and multidrug resistance-associated protein isoform 2 (MRP2).[2]
Mesaconitine has antinociceptive activity, has inhibition of stimulus-triggered and spontaneous epileptiform activity in rat hippocampal slices.[3,4]
Mesaconitine has antiinflammatory activity, can inhibit carrageenin-induced hind-paw edema in sham-operated mice as well as adrenalectomized mice, it do not affect the biosynthesis of the prostaglandins. [5]

[1] Mitamura M, Horie S, Sakaguchi M, et al. Eur J Pharmacol, 2013, 436(3):217-25.
[2] Ling Y, Yang X, Zhen Y, et al. Toxicol Lett, 2013, 216(2-3):86-99.
[3] Suzuki Y, Oyama T, Ishige A, et al. Planta Med, 1994, 60(5):391-4.
[4] Ameri A. Eur J Pharmacol, 1998, 342(2-3):183-91.
[5] Hiroshi H, Hiroshi T, Mitsuo F, et al. Eur J Pharmacol, 1982, 82(1-2):65-71.
[6] Zhou J, Ling Y E, Tang L, et al. China Journal of Traditional Chinese Medicine & Pharmacy, 2013, 38(10):1521-5.