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Deacetylasperulosidic acid

CAS No.:14259-55-3

Deacetylasperulosidic acid
Catalogue No.: BP0457
Formula: C16H22O11
Mol Weight: 390.341
Botanical Source: Morindae Officinalis Radix
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Synonym name:
Catalogue No.: BP0457
Cas No.: 14259-55-3
Formula: C16H22O11
Mol Weight: 390.341
Botanical Source: Rubia peregrina and Rubia tinctorum

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams.

For Reference Standard and R&D, Not for Human Use Directly.
Inquire for bulk scale.

 

​Description:

Deacetylasperulosidic acid inhibits the reduction of ear swelling, and also cancels the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext. Deacetylasperulosidic acid may increase catalase activity.

 

References:

Nat Prod Commun. 2014 Apr;9(4):445-50.    

Activation of cell-mediated immunity by Morinda citrifolia fruit extract and its constituents.   

Morinda citrifolia, commonly known as noni, is a traditional natural medicine in French Polynesia and Hawaii. Functional foods derived from M. citrifolia fruit have been marketed to help prevent diseases and promote good health. 

METHODS AND RESULTS:

The objective of this study was to assess the effects of M. citrifolia fruit on cell-mediated immunity. In the picryl chloride-induced contact dermatitis test, M. citrifolia fruit extract (Noni-ext) inhibited the suppression of cell-mediated immunity by immunosuppressive substances isolated from freeze-dried ascites of Ehrlich carcinoma-bearing mice (EC-sup). In addition, Noni-ext inhibited reduction of IL-2 production in EC-sup-treated mice and activated natural killer cells in normal mice. 

CONCLUSIONS:

These results suggest that Noni-ext has multiple effects on the recovery of cell-mediated immunity. Furthermore, we investigated the active principles of Noni-ext and identified an iridoid glycoside, Deacetylasperulosidic acid. Oral administration of Deacetylasperulosidic acid inhibited the reduction of ear swelling, and also cancelled the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext.