Product name: Brevifolincarboxylic acid
Synonym name:
Catalogue No.: BP1710
Cas No.: 18490-95-4
Formula: C₁₃H₈O₈
Mol Weight: 292.199
Botanical Source: "Isol from Caesalpinia brevifolia, Mallotus repandus"
Physical Description:
Type of Compound:

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.

Description:

Brevifolincarboxylic acid shows moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony, it (IC50 = 18.0 uM) also shows good antioxidant activity. Brevifolincarboxylic acid shows marked inhibitory effects on aryl hydrocarbon receptor -based bioassay activation by TCDD, and its effect is dose dependent.

References:

African Journal of Biotechnology, 2007 , 6 (14) :1685-1689.    

In vitro assays for bioactivity-guided isolation of antisalmonella and antioxidant compounds in Thonningia sanginea flowers   

Bioguided fractionation of the aqueous extract of Thonningia sanguinea flowers, used traditionally in the treatment of microbial diseases, led to the isolation of two phenolic compounds. 

METHODS AND RESULTS:

The structure of these compounds was elucidated by 1H, 13C 1D NMR and mass spectrometry experiments. The antibacterial activity against Salmonella strains and antioxidant activity of the crude extract, fractions and isolated compounds was evaluated using the DPPH method. The isolated compounds identified as Brevifolincarboxylic acid and gallic acid demonstrates moderate antibacterial activity against Salmonella enteritidis , Salmonella typhimurium , and Salmonella abony . 

CONCLUSIONS:

The results indicated that the two isolated compounds, gallic acid (IC50 = 13.5 μM) and Brevifolincarboxylic acid (IC50 = 18.0 μM) were mainly responsible for the good scavenging activity of the aqueous extract.    

Biol Pharm Bull. 2003 Dec;26(12):1754-60.    

Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.    

The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to environmental contaminants such as dioxins, which have many adverse health effects. 

METHODS AND RESULTS:

We performed a preliminary screening of the inhibitory effects of vegetable constituents on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of AhR using the AhR-based bioassay for dioxins, the Ah-Immunoassay. Ninety vegetable constituents including flavonoids, tannins, saponins, terpenes, etc., were assayed in vitro. Among them, flavones, flavonols, anthraquinones, piperine, coumestrol, Brevifolincarboxylic acid, and resveratrol showed marked inhibitory effects on AhR-based bioassay activation by TCDD, and their effects were dose dependent. Curcumin, carnosol, and capsaicin also inhibited the activation of AhR in this assay, although to a lesser degree. 

CONCLUSIONS:

These results suggest that several vegetable constituents might play a role in protection against dioxin toxicity.