Product name: Gypsogenin 3-O-β-D-glucuronopyranoside
Synonym name: Gypsogenin 3-O-β-D-glucuronopyranoside; Methyl gypsogenin 3-O-beta-D-glucuronopyranoside; Gypsogenin3-O-β-D-glucuronide 6'-methyl ester; Gypsogenin-3-O- β-D-glucuronide methyl ester
Catalogue No.: BP3177
Cas No.: 96553-02-5
Formula: C₃₇H₅₆O₁₀
Mol Weight: 660.845
Botanical Source:
Physical Description: Powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams. Inquire for bulk scale.
We provide solution to improve the water-solubility of compounds, thereby facilitating the variety of activity tests and clinic uses.

For Reference Standard and R&D, Not for Human Use Directly.

Description:

Gypsogenin 3-O-beta-D-glucuronopyranoside shows inhibitory activity toward pancreatic lipase with IC50 value of 0.29 mM, and the free carboxylic acid groups in position 28 within its chemical structures are required for enhancement of pancreatic lipase inhibition.

References:

Chem. Pharm. Bull. (Tokyo).,2007, 55(7):1087-9.    

Pancreatic lipase-inhibiting triterpenoid saponins from fruits of Acanthopanax senticosus.   

Sixteen triterpenoid saponins were isolated from the fruits of Acanthopanax senticosus, including a new compound, acanthopanaxoside E (1), which was established as 3-O-beta-D-glucuronopyranosyl echinocystic acid 28-O-beta-D-glucopyranoside on the basis of various spectroscopic analyses and chemical degradation. 

METHODS AND RESULTS:

By using a pancreatic lipase-inhibiting assay system, the crude saponin fraction showed inhibitory activity on pancreatic lipase, which is a key enzyme in lipid digestion. Among the isolated compounds, silphioside F (2), copteroside B (3), hederagenin 3-O-beta-D-glucuronopyranoside 6'-O-methyl ester (4) and gypsogenin 3-O-beta-D-glucuronopyranoside (Methyl gypsogenin 3-O-beta-D-glucuronopyranoside,5) showed inhibitory activity toward pancreatic lipase with IC(50) values of 0.22, 0.25, 0.26 and 0.29 mM, respectively, and the free carboxylic acid groups in position 28 within their chemical structures were required for enhancement of pancreatic lipase inhibition.    

HPLC of Methyl Gypsogenin 3-O-β-D-glucuronopyranoside