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Ginsenoside Rh2

CAS No.:78214-33-2

Ginsenoside Rh2
Catalogue No.: BP0668
Formula: C36H62O8
Mol Weight: 622.884
Botanical Source: Ginseng Radix Et Rhizoma
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Product name: Ginsenoside Rh2
Synonym name:
Catalogue No.: BP0668
Cas No.: 78214-33-2
Formula: C36H62O8
Mol Weight: 622.884
Botanical Source: Panax ginseng (ginseng)
Physical Description: White powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.


The purity(assay) of  20%, 40% and 90%, 95% is available for food, nutrition and cosmetics request, except for R&D and reference standard.


Descriptions:
Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation; ginsenoside Rh2 can suppress RANKL-induced osteoclast differentiation in vitro and in vivo through the regulation of c-Fos and NFATc1 expressions, not excluding the involvement of NF-κB and ERK, it is also suggested to be developed as a therapeutic drug for prevention and treatment of osteoporosis.[1]
Ginsenoside Rh2 has antitumor, antidiabetic, antiallergic, and anti-inflammatory effects; however, the extremely poor oral bioavailability induced by its low water solubility greatly limits the potency of Rh2 in clinical use, the sulfated modification of Rh2 improved its water solubility and the sulfated derivatives could be more potential candidates for developing as anti-inflammatory agents.[2]
Ginsenoside Rh2 potently protects ischemia-reperfusion brain injury, also inhibits prostaglandin-E_2 synthesis in lipopolysaccharide-stimulated RAW264.7 cells, suggests it can improve ischemic brain injury.[3]
Ginsenoside Rh2 potently reverses memory impairment caused by scopolamine, it might improve learning deficits, also have the memory-enhancing effects of RGB.[4]
Ginsenoside Rh2 can suppress growth of uterine leiomyoma in vitro and in vivo and may regulate ERα/c-Src/p38 MAPK activity.[5]
Ginsenoside Rh2 can inhibit the tendency of apoptosis, and reverse the impaired β-cell growth potential by modulating Akt/Foxo1/PDX-1 signaling pathway and regulating cell cycle proteins, suggests its therapeutic potential in the treatment of diabetes.[6]

References:
[1] Long He, Junwon Lee, Jae Hyuk Jang,et al. Bone, 2012, 50(6):1207-13.
[2] Fu B D, Bi W Y, He C L, et al. Fitoterapia, 2013, 84(3):303-7.
[3] Park E K, Choo M K, Oh J K, et al. Biol Pharm Bull, 2004, 27(3):433-6.
[4] Yang J H, Han S J, Ryu J H, et al. Biol Pharm Bull, 2009, 32(10):1710-5.
[5] Zhu Y, Xu J, Li Z, et al. J Funct Foods, 2015, 18:73-82.
[6] Wang Y, Wang H, Liu Y, et al. Horm Metab Res, 2012, 44(1):33-40.
[7] H Li, P Y Li, P Yong. Natural Products Chemistry & Research, 2014, 1(1):1-5.


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