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Home > Literature List > In Vitro Permeation and Skin Retention of α-Mangostin Proniosome

In Vitro Permeation and Skin Retention of α-Mangostin Proniosome

Journal name:Chemical and Pharmaceutical Bulletin
Literature No.:
Literature Url: https://www.jstage.jst.go.jp/article/cpb/64/12/64_c16-00425/_html
Date publication:20161201

The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1.8- to 8.0-fold as compared to the control suspension. Furthermore, incorporation of soya lecithin in the proniosomal formulation significantly enhanced the viable epidermis/dermis (VED) concentration of α-mangostin. All the proniosomal formulations (except for S20L) had significantly (p<0.05) enhanced deposition of α-mangostin in the VED layer with a factor range from 2.5- to 2.9-fold as compared to the control suspension. Since addition of Spans and soya lecithin in water improved the solubility of α-mangostin, this would be related to the enhancement of skin permeation and skin concentration of α-mangostin. The choice of non-ionic surfactant in proniosomes is an important factor governing the skin permeation and skin retention of α-mangostin. These results suggested that proniosomes can be utilized as a carrier for highly lipophilic compound like α-mangostin for topical application.


... The performances of α-mangostin proniosome were related to the solubility of α-mangostin in the non-ionic surfactants and soya lecithin. Page top. Experimental. Materials. α-Mangostin (98% purity) was purchased from Biopurify Phytochemicals Ltd., Chengdu, China. ...[Google+] [Facebook] [Twitter]
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