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Home > Literature List > Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile

Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile

Journal name:Food and Chemical Toxicology
Literature No.:
Literature Url: http://www.sciencedirect.com/science/article/pii/S027869151730248X
Date publication:11 May 2017
Vitex spp. have been reported as constituents of herbal preparations, namely Vitex peduncularis, commonly used in Asian countries. Unlike other species extensively investigated, reports on the biological activities and chemical profile of V. peduncularisare still scarce. In this work, the polyphenolic profile of V. peduncularis stem bark was unveiled, revealing a high content of apigenin and luteolin derivatives. More than 20 polyphenols were identified and quantitated for the first time, including C-rhamnosyl flavones infrequently reported. Regarding potential anti-inflammatory properties, the methanolic extract of the stem bark significantly reduced the levels of NO in macrophages, which may be a consequence of scavenging effect upon radical dotNO. Significant inhibition of phospholipase A2 activity was also noted. Consequently, the therapeutic applicability of this edible plant is also broadened due to the anti-inflammatory properties found.


... Louis, MO, US). 2.2. Phytochemical standards. Chlorogenic acid and 3,5-di-caffeoylquinic acid were obtained from Chengdu Biopurify Phytochemicals Ltd. (Sichuan, China). Vicenin-2 was from HWI Analytik GMBH (Rülzheim, Germany). ...