+86-28-82633987sales@biopurify.com
Batch Structure Search
Home > Literature List > Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort

Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort

Journal name:OR SURG OR MED OR PA.
Literature No.:
Literature Url: http://www.sciencedirect.com/science/article/pii/S2212440312015222
Date publication:2013 Feb.


?Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort

Xiao-Wen Jiang, PhD, DDS, Yi Zhang, MD, Ya-Li Zhu, MD, Hao Zhang, MD,Kun Lu, MD, Fen-Fang Li, MD, Hai-Yan Peng, MD

ABSTRACT

Objective

Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease, yet effective therapeutic approaches are lacking. This study aimed to determine the effects of application of berberine gelatin in the treatment of minor RAS (MiRAS).

Methods

A randomized, double-blind, placebo-controlled, clinical trial was performed. The gelatin containing berberine (5 mg/g) or vehicle only was applied 4 times per day for 5 days. Clinical evaluation included pain level, size, erythema, and exudation of certain ulcers on days 1, 2, 4, and 6.

Results

A total of 84 subjects fulfilled the study without obvious side effects. Berberine gelatin treatment reduced the ulcer pain score compared with placebo gelatin (P < 0.05). Ulcer size was significantly reduced (P < 0.05) and lower erythema (P < 0.05) and exudation (P < 0.05) levels were associated with berberine treatment.

Deacetylasperulosidic acid (1) (Fig. 1) was purchased from Chengdu Biopurify Phytochemicals Ltd. (Sichuan, China).

Related Products