+86-28-82633987sales@biopurify.com
Batch Structure Search
Home > Literature List > Platycodi Radix and its active compounds ameliorate against house dust mite-induced allergic airway inflammation and ER stress and ROS by enhancing anti-oxidation

Platycodi Radix and its active compounds ameliorate against house dust mite-induced allergic airway inflammation and ER stress and ROS by enhancing anti-oxidation

Journal name:Food and Chemical Toxicology
Literature No.:
Literature Url: https://doi.org/10.1016/j.fct.2018.11.001
Date publication:November 2018
Abstract

Allergic airway inflammation is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. The endoplasmic reticulum (ER) is involved in protein synthesis and maturation, and is a susceptible to sub-organelle stress including inflammation and ROS-amplifying signaling. Here, the effects of Platycodi Radix extracts (PRE) on house dust mite (HDM) extract (Dematophagoides pteronyssius)-induced asthma were investigated. Following 50, 100, or 200 mg/kg-PRE-treatment, the infiltration of inflammatory cells, ER stress, and NF-κB signaling were controlled. The expression of inflammatory cytokines and mucin5AC was also inhibited in the presence of PRE. Consistently, in the HDM-exposed human bronchial epithelial cells, ER stress and its associated ROS were significantly increased along with NF-κB signaling, which was also attenuated by PRE and its components. This study suggests that PRE might be useful as a therapeutic/preventive agent in HDM-associated allergic airway inflammation. ER stress and its associated ROS signaling involved in inflammation provide additional mechanistic insight into the underlying molecular mechanism.

… against asthma in humans. 2. Materials and methods. 2.1. Materials. Platycoside E (PLE) and platycodin D 3 (PLD) were purchased from Chengdu Biopurify Phytochemicals Ltd. (Chengdu, China). Primary antibodies targeting … 

 
Related Products