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Home > Literature List > Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL/6 Mice

Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL/6 Mice

Journal name:Evidence-Based Complementary and Alternative Medicine
Literature No.:
Literature Url: http://scholar.google.com/scholar_url?url=https://www.hindawi.com/journals/ecam/2020/2938432/&hl=zh-CN&sa=X&d=16071236360037959209&scisig=AAGBfm0UVAH_SLNI75J27kExD59ASc1YDg&nossl=1&oi=scholaralrt&hist=P1l9U8wAAAAJ:6061410958341296950:AAGBfm1SMj-qIFykR7xxSgbekTZuDQdibA
Date publication:28 Feb 2020
Abstract

Oxidative stress (OS) is a crucial factor influencing the development of Parkinson’s disease (PD). Here we first reported that Lindleyin (Lin), one of the major components of rhubarb, possessed neuroprotective effects against H2O2-induced SH-SY5Y cell injury and MPTP-induced PD of C57BL/6 mice. The results showed that Lin can decrease cell death and apoptotic rate induced by H2O2 through inhibiting mitochondrial apoptotic pathway and increasing the activities of SOD, GSH-Px, and CAT as well as decreasing the level of MDA. In addition, in vivo studies showed that oral administration of Lin (5 or 20 mg/kg) showed significant change in motor function deficits, antioxidant enzyme activities, apoptotic pathway, and tyrosine hydroxylase expression. Our results reveal that Lin might be a promising anti-PD agent by reducing OS and apoptosis.

… These findings reveal that Lin is a promising lead compound with potent ability of anti-OS for PD treatment. 2. Methods. 2.1. Antibodies and Reagents. Lindleyin (Lin) was gained from the Chengdu Biopurify Phytochemicals Ltd. (>98.2%) …
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