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Characterization and Anti-stroke Activity of Stem Extract of Colebrookea oppositifolia Smith

Journal name:Journal of Biologically Active Products from Nature
Literature No.:
Literature Url: https://www.tandfonline.com/doi/abs/10.1080/22311866.2020.1791731
Date publication:13 Jul 2020

AbstractThis study was aimed to investigate the cerebroprotective potential of methanolic stem extract of Colebrookea oppositifolia (MsCO). The MsCO was evaluated against global ischemia and reperfusion (I/R) induced brain injury in Wistar rats. In the outcomes, the I/R insult caused significant deterioration of neurological (p<0.01), cognitive (p<0.01), and motor functions (p<0.01), along with significant alterations in the antioxidant parameters (decreased SOD and catalase enzyme activities, along with derease in GSH and increase in LPO; p<0.01 for all parameters), morphology (cerebral edema and infarct area) (p<0.01) and histology of the brain tissue in the I/R control group compared to normal control. Interestingly, the MsCO (200 and 400 mg/kg) pretreatment for seven days has attenuated all the I/R-induced alterations significantly and dose-dependently compared to I/R control group. Moreover, the LC-MS/MS analysis of MsCO revealed the presence of Acteoside, Pentagalloyl glucose, and Quercetin as major phytoconstituents. Based on these outcomes we conclude that MsCO possesses potent cerebroprotective activity against ischemia-reperfusion-induced brain injury in Wistar rats.

… oppositifolia in Wistar rats. Materials and methods Drugs and chemicals Acteoside, pentagalloyl glucose, quercetin was procured from Ms. Chengdu Biopurify Phyto-chemicals Ltd. (Sichuan, China). All the liquid chromatography … 
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