Batch Structure Search
Home > Product Category > Botanical Source > Zanthoxyli pericarpium


CAS No.:80554-58-1

Catalogue No.: BPF7283
Formula: C17H23NO
Mol Weight: 257.377
Botanical Source: Zanthoxyli pericarpium
+86-28-82633860  +86-18080483897
Email: sales@biopurify.com biopurify@gmail.com
We have been the main supplier of phytochemicals worldwide for more than 10 years, please feel free to contact us!

Product name: Schinifoline
Synonym name: 1-Methyl-2-heptyl-4(1H)-quinolinone
Catalogue No.: BPF7283
Cas No.: 80554-58-1
Formula: C17H23NO
Mol Weight: 257.377
Botanical Source:
Physical Description:
Type of Compound: Alkaloids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
The product could be supplied from milligrams to grams
Inquire for bulk scale.

For Reference Standard and R&D, Not for Human Use Directly.



Schinifoline has cytotoxic activity, it also shows in vitro radiosensitising, cell cycle and apoptotic-inducing effects.



Molecules. 2014 Dec 1;19(12):20128-38.    

Radiosensitizing effect of schinifoline from Zanthoxylum schinifolium Sieb et Zucc on human non-small cell lung cancer A549 cells: a preliminary in vitro investigation.    

Schinifoline (SF), a 4-quinolinone derivative, was found in Zanthoxylum schinifolium for the first time. 4-Quinolinone moieties are thought to have cytotoxic activity and are often used as a tubulin polymerization inhibitors, heterogeneous enzyme inhibitors and antiplatelet agents. However, very little information respect to radiosensitization has focused on SF. 


This work aimed to investigate the radiosensitizing effect of SF on A549 cells. The cell viability results indicated cytotoxicity of SF on A549 cells, with IC50 values of 33.7 ± 2.4, 21.9 ± 1.9 and 16.8 ± 2.2 μg/mL, respectively, after 6, 12, 24 h treatment with different concentrations, and the 10% or 20% IC50 concentration during 12 h was applied in later experiments. The results of cell proliferative inhibition and clonogenic assay showed that SF enhanced the radiosensitivity of A549 cells when applied before 60Co γ-irradiation and this effect was mainly time and concentration dependent. The flow cytometric data indicated that SF treatment before the irradiation increased the G2/M phase, thus improving the radiosensitivity of A549, leading to cell apoptosis.


This paper is the first study that describes the in vitro radiosensitising, cell cycle and apoptotic-inducing effects of Schinifoline.