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Heme oxygenase 1-mediated novel anti-inflammatory activities of Salvia plebeia and its active components

Journal name:J ETHNOPHARMACOL.
Literature No.:
Literature Url: http://www.sciencedirect.com/science/article/pii/S0378874115300969
Date publication:2015 Aug.28.


Heme oxygenase 1-mediated novel anti-inflammatory activities of Salvia plebeia and its active components

Muhammad Akram, Ahmed Shah Syed, Kyeong-A Kim, Jong Soo Lee, Sun-Young Chang, , Chul Young Kim, , Ok-Nam Bae, , 

Abstract

Ethnopharmacological relevance

Salvia plebeia R. Br. (SP) has been widely used as a traditional folk medicine for the treatment of infectious diseases and pain. An anti-inflammatory potential of SP has remains largely unknown.

Aim of the study

We tried to elucidate the principle mechanism and the active ingredients underlying the anti-inflammatory activities of SP.

Materials and Methods

We investigated the protective activities of SP methanolic extract (SPME) and seven representative ingredients against inflammation. Quantitative analysis

The standard compounds luteoloside, nepitrin, homoplantagenin, luteolin, nepetin, hispidulin, and eupatorin were purchased from Chengdu Biopurify Phytochemicals Ltd (Chengdu, China).