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calycosin-7-O-beta-D-glucoside

CAS No.:20633-67-4

calycosin-7-O-beta-D-glucoside
Catalogue No.: BP0306
Formula: C22H22O10
Mol Weight: 446.408
Botanical Source: Astragali radix
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Product name: calycosin-7-O-beta-D-glucoside
Synonym name: Calycosin-7-O-β-D-glucoside; Calycosin 7-glucoside
Catalogue No.: BP0306
Cas No.: 20633-67-4
Formula: C22H22O10
Mol Weight: 446.408
Botanical Source: Baptisia and Thermopsis spp.
Physical Description: Powder
Type of Compound: Flavonoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Calycosin-7-O-β-d-glucoside(CG) treatment can significantly reduce infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia–reperfusion rat model; inhibit the expression and activities of MMPs, and secure the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex; scavenge NO, inhibit the activities of MMP-2 and MMP-9, and attenuate cell death in the in vitro cultured brain microvascular endothelial cells under OGD condition; thus CG could protect BBB integrity in experimental cerebral ischemia–reperfusion injury via regulating NO/cav-1/MMPs pathway.[1]
Calycosin-7-O-β-D-glucoside can promote oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells.[2]
Calycosin-7-O-β-d-glucoside attenuates ischemia-reperfusion injuryin vivovia activation of the PI3K/Akt pathway.[3]
Calycosin-7-O-β-D-glucoside has effects on cell apoptosis in cervical cancer HeLa cells and expression of Bcl-2/Bax.[4]

References:
[1] Fu S, Gu Y, Jiang J Q, et al. J Ethnopharmacol. 2014,155(1): 692–701.
[2] Jiang Y H, Sun W, Li W, et al. Bmc Compl Altern M, 2015, 15(1):1-11.
[3] Ren M, Wang XD, Du G Q, et al. Mol Med Rep, 2015, 13(1):235–45.
[4] Zhang D M. Chinese Traditional & Herbal Drugs, 2015, 46(10):1498-502.
[5] Song C Y, Feng J F. Chinese J Exp Trad Med Formulae, 2013, 19(11):115-7.


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