Product name: Gastrodin
Synonym name: 4-β-D-Glucopyranosyloxybenzyl alcohol
Catalogue No.: BP0627
Cas No.: 62499-27-8
Formula: C13H18O7
Mol Weight: 286.28
Botanical Source: Gastrodia elata and Galeola septentrionalis
Physical Description: Powder
Type of Compound: Phenols
Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.
Descriptions:
Gastrodin has anti-inflammatory activity, can significantly attenuate levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-κB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells, suggests that gastrodin has a potential as an anti-inflammatory drug candidate in neurodegenerative diseases.[1]
Gastrodin protects midbrain of MPTP-intoxicated mice against oxidative stress, in part, through interrupting ERK1/2–Nrf2 pathway mechanism, which will give us an insight into the potential of gastrodin in terms of opening up new therapeutic avenues for PD.[2]
Gastrodin is one of the natural compound isolated from Gastrodia elata and has anticonvulsant effects, it may cause the elevation of GABA concentration by inhibiting the GABA shunt.[3]
Gastrodin activates PI3-K/Akt signaling and that inhibition of this pathway reverses the inhibitory effects of gastrodin on NF-κB and MAPKs activation in H9c2 cardiomyocytes.[4]
Gastrodin can inhibit allodynia and hyperalgesia in painful diabetic neuropathy rats by decreasing excitability of nociceptive primary sensory neurons.[5]
Gastrodin has protective effect to the prevention of neurotoxicity induced by ischemic stroke, the mechanism is by improving anti-oxidant and anti-inflammation activities, inhibiting apoptosis pathway, and increasing Akt phosphorylation and Nrf2 expression.[6]
References:
[1] Dai J N, Zong Y, Zhong L M, et al. Plos One, 2011, 6(7):e21891.
[2] Wang X L, Xing G H, Hong B, et al. Life Sci, 2014, 114(2):77-85.
[3] An S J, Park S K, Hwang I K, et al. J Neurosci Res, 2003, 71(4):534–43.
[4] Yang P, Han Y, Gui L, et al. Biochem Pharmacol, 2013, 85(8):1124-33.
[5] Sun W, Miao B, Wang X C, et al. Plos One, 2012, 7(6):e39647.
[6] Peng Z, Wang S, Chen G, et al. Neurochem Res, 2015, 40(4):661-73.
[7] Ju X H, Shi Y, Liu N, et al. J Chromatogr B , 2010, 878(22):1982-6.
