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Ingenol

CAS No.:30220-46-3

Ingenol
Catalogue No.: BP0765
Formula: C20H28O5
Mol Weight: 348.439
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Synonym name:
Catalogue No.: BP0765
Cas No.: 30220-46-3
Formula: C20H28O5
Mol Weight: 348.439
Botanical Source: Semen Euphorbia L.

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle
Can be supplied from milligrams to grams, up to kilograms.
It can be manufactured in GMP plant on request.

For R&D, not for human use Directly!


Typical COA:

 Ingenol-coa-13110701.pdf 

 

References:
1, Synthesis of ingenol analogs wth affinity for protein kinase C
    Volume 3, Issue 4, April 1993, Pages 577–580
Abstract
The synthesis and preliminary evaluation of the first biologically active analogs of ingenol are described. Both saturated and unsaturated compounds containing both the C-3 and C-20 oxygen functionalities of ingenol have substantial affinity for protein kinase C.

2, Upregulation of HIV-1 replication in chronically infected cells by ingenol derivatives
    Archives of Virology  October 1998, Volume 143, Issue 10, pp 2003-2010
Abstract
We have previously reported that ingenol derivatives are highly potent inhibitors of human immunodeficiency virus type 1 (HIV-1) replication in acutely infected cells. In this study, however, we have found that some ingenol derivatives strongly enhance the replication of HIV-1 in chronically infected cells at nanomolar concentrations. One of the derivatives could activate nuclear factor κB(NF-κB), a potent inducer of HIV-1 replication, through the activation of protein kinase C (PKC). Whereas another derivative, which affected neither PKC nor NF-κB, significantly enhanced HIV-1 replication, suggesting that a PKC-independent mechanism may also exist in ingenol derivative-induced HIV-1 upregulation.

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