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Arctiin

CAS No.:20362-31-6

Arctiin
Catalogue No.: BP0187
Formula: C27H34O11
Mol Weight: 534.558
Botanical Source: Arctium lappa L.
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Product name: Arctiin
Synonym name:
Catalogue No.: BP0187
Cas No.: 20362-31-6
Formula: C27H34O11
Mol Weight: 534.558
Botanical Source: Arctium lappa L.(Burdock).
Physical Description: Powder
Type of Compound: Lignans

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Arctiin, a lignan isolated from Arctium lappa (burdock) seeds, has a protective effect on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) -induced carcinogenesis particularly in the mammary gland in the promotion period, it may have a weak co-carcinogenic influence on MeIQx-induced hepatocarcinogenesis. [1]
Arctiin has been reported to have anti-inflammatory, anti-oxidant, antibacterial, and antiviral effects in vitro, it may exert anti-inflammatory effect by inhibiting the pro-inflammatory mediators through the inactivation of NF-kB.[2]
Arctiin significantly induces cell detachment and decreases the cell numbers via the up-regulation of MUC-1 mRNA and protein in PC-3 cells.[3]
Arctiin down-regulates cyclin D1 protein expression and that this at least partially contributes to the anti-proliferative effect of arctiin.[4]
Arctiin has ameliorative effects on glomerulonephritis is carried out mainly by suppression of NF-κB activation and nuclear translocation and the decreases in the levels of these pro-inflammatory cytokines, while SOD is involved in the inhibitory pathway of NF-κB activation; arctiin has favorable potency for the development of an inhibitory agent of NF-κB and further application to clinical treatment of glomerulonephritis, though clinical studies are required.[5]
Arctiin induces an UVB protective effect in human dermal fibroblast cells through microRNA expression changes.[6]
Arctigenin and arctiin have antiproliferative effect.[7]

References:
[1] Hirose M, Yamaguchi T, Cui L, et al. Cancer Lett, 2000, 155(1):79-88.
[2] Lee S, Shin S, Kim H, et al. J Inflamm, 2010, 8(1):321-4.
[3] Huang D M, Guh J H, Chueh S C, et al. Prostate, 2004, 59(3):260-7.
[4] Matsuzaki Y, Koyama M, Hitomi T, et al. Oncol Rep, 2008, 19(3):721-7.
[5] Wu J G, Wu J Z, Sun L N, et al. Phytomed Int J Phytother Phytopharmacol, 2009, 16(11):1033-41.
[6] Lee G T, Cha H J, Lee K S, et al. Int J Mole Med, 2014, 33(3):640-8.
[7] Shi Y R, Ahn J W, Kang Y H, et al. Arch Pharml Res, 1995, 18(6):462-3.
[8] Zheng L, Song Y. Pharm Clin Chinese Mat Med, 2011, 02(2):23-6.