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Ginsenoside CK

CAS No.:39262-14-1

Ginsenoside CK
Catalogue No.: BP0651
Formula: C36H62O8
Mol Weight: 622.884
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Product name: Ginsenoside CK
Synonym name: Ginsenoside C-K; Ginsenoside Compound k
Catalogue No.: BP0651
Cas No.: 39262-14-1
Formula: C36H62O8
Mol Weight: 622.884
Botanical Source: Prod. from saponins of Gynostemma pentaphyllum by endogenous glycosidases
Physical Description: White powder
Type of Compound: Triterpenoids

Purity: 95%~99%
Analysis Method: HPLC-DAD or/and HPLC-ELSD
Identification Method: Mass, NMR
Packing: Brown vial or HDPE plastic bottle

Storage: Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

The product could be supplied from milligrams to grams, up to kilograms
Inquire for bulk scale.

Descriptions:
Ginsenoside compound K (C-K) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes; C-K acts as a unique HUVEC migration inhibitor by regulating MMP expression, as well as the activity of SPHK1 and its related sphingolipid metabolites.[1]
Ginsenoside compound K, the intestinal metabolite of ginseng saponin, has various chemopreventive and chemotherapeutic activities, including anti-tumor activity; C-K suppresses the activation of the NF-κB pathway, may become a potential cytotoxic drug in the prevention and treatment of hepatocellular carcinoma( HCC).[2]
Ginsenoside compound K shows significant anti-proliferative effects and pro
-apoptotic effects in HCT-116 and SW-480 cells at concentrations of 30-50 uM, suggests that C-K could be potentially effective anti-colorectal cancer agent.[3]
Ginsenoside CK has anti-cancer effect on NPC cells, C-K-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo.[4]

References:
[1] Shin K O, Seo C H, Cho H H, et al. Arch Pharm Res, 2014, 37(9):1183-92.
[2] Ming Y, Chen Z, Chen L, et al.Planta Med, 2011, 77(5):428-33.
[3] Wang C Z, Du G J, Zhang Z, et al.Int J Oncol , 2012, 40(6):1970-6.
[4] Law K M, Kwok H H, Poon P Y, et al. Chinese Medicine, 2014, 9(1):1-9.
[5] Zhou W, Luo Z S, Zhou P, et al. Chromatogram, 2005, 23(3):270-2.


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